AutoGen vs AWS Bedrock AgentCore: Which Agent Framework to Use?

AutoGen and AWS Bedrock AgentCore both let you build an agent, but they sit in different parts of the stack and they assume different things about who's writing the code.

AutoGen by Microsoft models agents as ConversableAgents that chat with each other.

Bedrock AgentCore is AWS's managed runtime for production agents, launched in July 2025.

Underneath, both wrap the same thing: a model call, a tool dispatch, a loop. The decision is about which abstraction your team wants to think in day to day, and which ecosystem you're willing to inherit along with it. There's an honest, framework-free version of the same pattern in about 60 lines of Python in the lesson at the bottom of this page — useful as a baseline regardless of which framework wins.

Pick AutoGen if autoGen excels at complex multi-agent workflows where agents need to debate or collaborate. For single-agent use cases or simple tool-calling agents, the plain Python version is significantly simpler. The tradeoffs in its intro should match how your team already thinks about agents; AWS Bedrock AgentCore will feel like translation if they don't.

Pick AWS Bedrock AgentCore if agentCore is for production AWS deployments where you want to skip the runtime, memory, identity, and observability work and pay AWS to do it instead. It is framework-agnostic — bring Strands, LangGraph, CrewAI, or your own. For non-AWS teams, prototypes, or anything where you want to see what the agent is doing, plain Python on Lambda or a container is simpler. The tradeoffs in its intro should match how your team already thinks about agents; AutoGen will feel like translation if they don't.

Whichever you pick, you're inheriting a dependency tree and a vocabulary your team has to learn before they ship anything. AutoGen has its own class hierarchy and tool registration conventions; AWS Bedrock AgentCore has its. Either way, when something misbehaves you'll be reading framework source before you reach the actual HTTP call.

If the real workload is one model and a handful of tools, both can feel like a workbench for driving a nail. The lesson below builds the same pattern in plain Python — useful as a comparison point even if you ultimately keep the framework.